Test 3

Perinatal disorders

Questions marked with * are more appropriate for residents.
1. Asphyxia means pulselessness
A. True
B. False
2. A 36 week gestation fetus is more susceptible to HIE than a 40 year old person
A. True
B. False
3. Porencephaly is a developmental malformation occurring in the second trimester
A. True
B. False
4. The pathology illustrated below is a developmental malformation occurring in the second trimester
Porencephaly
A. True
B. False
5. Complications of germinal matrix hemorrhage occurring at 22 weeks of gestation include all of the following except:

A. Hydrocephalus due to blockage of the aqueduct
B. Psychomotor retardation from loss of neuronal and glial precursors
C. Porencephaly, due to disruption of the periventricular white matter
D. Fetal anemia from excessive blood loss
*6. A baby boy was born at 29 weeks of gestation and was discharged from the NICU at 34 weeks. At 7 months of age, spasticity of the lower extremities is apparent. The CT scan is shown below. The most likely cause of the abnormality is:
Diffuse PVL
A. X-linked hydrocephalus
B. Undetected prenatal infection
C. White matter damage due to ischemia
D. A metabolic disorder
*7. A 39 week pregnant woman detected decreased fetal movement. Biophysical profile was poor and the baby was delivered by Cesarean section with Apgar scores of 1 and 3 at 1 and 5 minutes. The baby was hypotonic, had poor respiratory effort, and died at 4 four days of gestation. Pathological examination revealed HIE. Which of the following would be least severely affected?

A. The hippocampus
B. The cerebral cortex
C. The thalamus
D. The brainstem
8. The white matter is most frequently affected by HIE in:
A. Premature infants
B. Adults
C. Both
D. Neither
9. This baby was born at 36 weeks of gestation and developed E. Coli sepsis and meningitis. He died two weeks later. The changes in the brain shown below are due
to:
Encephalomalacia
A. HIE
B. Cerebritis due to E. Coli
C. Both
D. Neither
10. This child was born at term and had spasticity and psychomotor retardation. He lived in an institution for retarded children and died at 12 years of age. The brain
lesion shown below is due to:
Schizencephaly
A. Congenital infection
B. Ischemia
C. A genetic disorder
D. Teratogen effect
11. This baby was born at term. He was hypotonic, had a large transilluminating head, and died at 2 days of age. The brain at autopsy is shown below. Which of the following statements about the brain pathology is not true:
Hydranencephaly
A. The primary lesion is extreme hydrocephalus
B. The lesion is due to destruction of cortex and aqueductal atresia
C. There may be preservation of the temporal lobe, brainstem and cerebellum
D. The infant may appear normal in the first day of life
12. This infant was born at 30 weeks of gestation and died three weeks later. The
brain lesions shown below represent:
Periventricular leukomalacia Periventricular leukomalacia
A. Congenital CMV
B. Congenital toxoplasmosis
C. A metabolic disorder
D. Ischemic pathology
13. This baby was born at 28 weeks of gestation. At 24 hours, he became hypotonic and his hematocrit dropped to 23. He died three days later. The pathology illustrated below is due to:
Intraventricular hemorrhage
A. Maternal immune thrombocytopenia
B. Germinal matrix hemorrhage
C. Birth injury
D. Congenital infection
14. The pathology in the brain of this six day old girl shown below may be caused
by:
Bilirubin encephalopathy
A. Deficiency of glucuronyl transferase
B. Congenital biliary atresia
C. Both
D. Neither

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