M2 NEUROPATHOLOGY COURSE

ANSWERS TO THE QUESTIONS

Quiz 1
A-5. MS
B-1. Cryptococcus meningitis
C-3. Frontal lobe abscess
D-4. Arterial aneurysm
E-2. Severe brain atrophy from HIE

Quiz 2
A-8. AVM
B-1. Bilateral lacunar infarcts
C-10. HSV encephalitis
D-9. Left MCA infarct, presumably embolic
E-7. Hypertensive pontine hemorrhage hemorrhage

Quiz 3
A-15. Bacterial meningitis
B-11. Multiple sclerosis and left cerebral infarct
C-14. Lacunar infarct, left basal ganglia and internal capsule
D-12. Subarachnoid hemorrhage
E-13. Hypertensive intracerebral hemorrhage

Quiz 4
A-18. Bacterial meningitis
B- 17. Candida albicans
C-16. Cryptococcus meningitis
D-20. CMV encephalitis
E-19. Neonatal HSV encephalitis. Intranuclear inclusion.

Quiz 5
A-22. Tuberculous meningitis
B-24. HSV encephalitis. Perivascular mononuclear cells.
C-21. Vascular narrowing post bacterial meningitis. The lesion begins as arteritis due to invasion of leptomeningeal vessels by neutrophils.
D-23. HIV encephalitis. Multinucleated giant cell.
E25-MS. Plaque.

Quiz 6
A-29. Diffuse low grade astrocytoma of the left basal ganglia and thalamus.
B-30. Glioblastoma.
C-27. Meningioma
D-26. Acoustic Schwannoma
E-28. Pituitary adenoma.

Quiz 7
A-35. Compression of the left hemisphere by subdural hematoma.
B-31. Cerebellar tonsillar herniation.
C-34. Bullet tract.
D-32. Contre coup contusion
E-33. Retinal and optic nerve hemorrhages in the shaken baby syndrome

Quiz 8
A-37. Diffuse axonal injury
B-40. Left temporal lobe herniation, compression of the left posterior cerebral artery, and left temporal-occipital lobe infarct.
C-39. Subarachnoid and intracerebral hemorrhage from a ruptured MCA aneurysm.
D-38. Compression of the left hemisphere from subdural hematoma.
E-36. Cerebellar tonsillar herniation with displacement of the fragmented tonsils into the spinal canal.

Quiz 9
A-42. Cerebral lymphoma.
B-45. Meningioma.
C-41. Glioblastoma multiforme; anaplasia and mitoses.
D-44. CSF metastases from medulloblastoma.
E-43. Meningeal carcinomatosis

Quiz 10
A-47. Diffuse axonal injury. Axonal swellings. Beta amyloid precursor protein immunostain.
B-50. Pilocytic astrocytoma. Microcysts.
C-48. Progressive multifocal leukoencephalopathy. Demyelinated areas.
D-49. Schwannoma. Palisading pattern.
E-46. Oligodendroglioma.

Quiz 11
A-55. Bilirubin staining of the dentate nuclei of the cerebellum.
B-54. Periventricular leukomalacia.
C-51. Porencephaly. Schizencephaly is also a correct answer.
D-52. Multicystic encephalomalacia.
E-53. Hydranencephaly

Quiz 12
A-56. Huntington’s disease. Atrophy of the caudate nuclei.
B-58. Normal pressure hydrocephalus.
C-57. MS
D-60. Parkinson’s disease. Loss of pigment in the substantia nigra.
E-59. Alzheimer’s disease. Cortical atrophy.

Quiz 13
A-64. AVM.
B-63. Mucormycosis. Fungal arteritis. PAS stain.
C-61. Bacterial meningitis
D-62. HIV encephalitis. Multinucleated giant cells.
E-65. Tuberculous meningitis.

Quiz 14
A-68. Duchenne muscular dystrophy. Myonecrosis.
B-70. Inflammatory myopathy-polymyositis.
C-66. GBS. Inflammation in a nerve.
D-67. Charcot-Marie-Tooth disease. Hypertrophic changes.
E-69. Spinal muscular atrophy. Denervation changes – fiber type grouping.

Quiz 15
A-73. Alzheimer’s disease. Bielschowsky stain showing plaque and tangle.
B-71. Parkinson’s disease. Lewy body
C-75. Multiple system atrophy. Cerebellar degeneration.
D-72. CJD. Spongiosis.
E-74. ALS. Degeneration of the corticospinal tracts.


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